Centre National de Recherche et de Formation sur le Paludisme (CNRFP)
The Centre National de Recherche et de Formation sur le Paludisme (CNRFP) is part of the Secretariat General of the Burkina Faso Ministry of Health. It was founded in 1982 with financial and technical support from the Directorate General for Co-operation to Development, Italian Ministry of Foreign Affairs (DOCS-MAE). The centre is one of the two leading malaria research institutions in the country.
The centre was founded to guide the development of the national malaria control programme and to support its implementation. The mandate of CNRFP is, therefore, to participate in the formulation, implementation, supervision, and evaluation of the national malaria control programme; to carry out operational and basic research to identify new malaria control tools and adapt existing ones to local conditions; and to provide training on malaria to healthcare providers and scientists from Burkina Faso and other African countries.
Current Activities of CNRFP
- Community based interventions (home management of malaria, prevention of malaria during pregnancy, insecticide treated materials)
- Training of local and regional health staff on malaria control strategies
- Training of local and international scientists and students
- Clinical trials (drugs and vaccines)
- Evaluating P.falciparum susceptibility to antimalarials (chloroquine, sulfadoxine-pyrimethamine) and the susceptibility of malaria vectors to insecticides
- Epidemiological and basic research on malaria
Currently, the CNRFP team consists of multi-disciplinary scientists, several post-doctoral fellows, and graduate students. Group members have also been trained for ICH-GCP, GLP and ethics during short term training sessions. Over the last five years, CNRFP has conducted many clinical trials with antimalarial drugs and have undertaken phase Ib on malaria vaccine candidates. Presently, the centre has at least 20 investigators able to conduct research study, which fulfills international regulatory requirements on principal investigators.
WANECAM STUDY SITES
The main study site will take place in the south-western part of the country in the Province of Comoé, located 441 km from Ouagadougou, the capital of Burkina Faso. The surface area of the province is 15871 km2 and the total population is 277 384 inhabitants (17% of which are children between 0 and 4 years old). The entire province is covered by the health district of Banfora and has 24 community clinics called Centre de Santé et de Promotion Sociale (CSPS). The Banfora district hospital is the first level of referral for community clinics. These health centres provide basic health care services such as child immunization, prenatal surveillance, delivery services, and family planning.
The Niangoloko Medical Center, the home of the WANECAM study site, is one of the advanced community clinics in Banfora’s health district and is located along the boarder between Burkina Faso and the Ivory Coast.
The study area belongs to the Sudan-Guinea zone with more than 900 mm of rain a year and cooler average temperatures. The malaria transmission is markedly seasonal; most transmission occurs during the rainy season from May to November and risk of transmission is low during the dry season from December to April. P. falciparum is the predominant malaria parasite accounting for more than 95% of infections in children under five years of age.